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Perfect the Art of Conversation in Spanish!

Nervous that you’re not ready to strike up a conversation with a native Spanish speaker? This book helps you overcome that obstacle and before you know it, you’ll be speaking comfortably in your new native language.

Practice Makes Perfect: Spanish Conversation is organized around twelve units that present realistic conversational situations, from making introductions to giving opinions and from making a date to telling a story. Using these engaging dialogues as a starting point, each unit is packed with helpful instruction on correct pronunciation, syntax, and word usage--in addition to lots of conversation-ready phrases that you will find indispensable as your fluency increases.

Practice Makes Perfect: Spanish Conversation will help you:

• Engage in dialogues that illustrate practical conversations
• Expand your vocabulary
• Get clarification of new concepts with numerous realistic examples
• Reinforce your new conversational skills through extensive exercises
• Improve your pronunciation through audio dialogs and exercises, via app and online

Before you know it, you’ll find yourself confidently speaking Spanish with your Spanish-speaking friends--or ready to make new ones!

• Sales Rank: #39240 in Books
• Published on: 2016-04-28
• Original language: English, Spanish
• Number of items: 1
• Dimensions: 10.70" h x .50" w x 8.40" l, .0 pounds
• Binding: Paperback
• 192 pages

About the Author
Jean Yates, Ph.D teaches Spanish at George Washington University and is the author of Beginning Spanish for the Utterly Confused, Better Reading Spanish, and Correct Your Spanish Blunders.

Most helpful customer reviews

8 of 8 people found the following review helpful.
What did I like most about this book
By Drew R.
[[VIDEOID:483070ccc19902c183cb20676528ef54]] Spanish Conversation is a book that will really help you to speak conversational Spanish. This book is filled with practical, everyday dialogues. You will learn Spanish words and phrases for real-life situations, such as:

- Meeting at a Party
- Expressing Your Opinions, Likes and Dislikes
- Striking Up a Conversation
- Making appointments and Informal Dates
- Discussing Roommates
- Narrating a Story About a Traffic Accident
- Retelling a conversation that took place between a mother and a kindergarten teacher

Another benefit about this book is that it has a ton of exercises to help reinforce the new Spanish words and phrases that I learned from the dialogs. Each of the book’s 12 chapters include between 10 and 12 exercises.

What did I like most about this book? Well, the Spanish that I learned was very practical. Many books teach Spanish that you’ll never use in a real-life situation. But this book taught me conversational Spanish - really useful Spanish - that I can use in typical, everyday situations when speaking to Spanish-speaking friends or acquaintances.

After using this book, I can assure you that you’ll find yourself speaking Spanish with greater confidence and speaking the language more spontaneously.

There is even an online section that will allow you to listen and improve your comprehension of spoken Spanish while also improving your pronunciation. It is one thing to read a conversation in Spanish but being able to actually listen to it in order to improve your listening comprehension is a completely different animal.

In closing, I want to leave you with a list of my favorite three learn-Spanish products available here at Amazon:

1. Easy Spanish Phrase Book NEW EDITION: Over 700 Phrases for Everyday Use (Dover Language Guides Spanish) Easy Spanish Phrase book. This is an economically priced, handy resource that easily fits into my back pocket. You can conveniently take it anywhere with you when vacationing in a Spanish speaking country in order to have more than 700 phrases in your Spanish-vocabulary arsenal. And unlike so many learning-Spanish books, there is also a section called "Computers and Technology" where you'll find Spanish vocabulary related to modern technology.

2. Learning Spanish Like Crazy Level 1 CDR - w/ Super Bonus Package - Learn Spanish & Speak Spanish - New & Improved for PC/Mac - Free Updates for 1 Yr LSLC is my favorite audio Spanish program because the program focuses on everyday, Latin American Spanish. This is a new and improved version with new content and new native Spanish speakers, and I find it to be much better than the previous version. The program is geared toward the foreign-language learner who wants to eventually achieve fluency in Spanish instead of someone who just wants to learn a few travel phrases. Compared to the other programs that I have used, this one does the best job at teaching you how to develop an authentic sounding Latin American Spanish accent. The program also comes with a very impressive bonus package.
.

3. 501 Spanish Verbs with CD-ROM and Audio CD (501 Verb Series) 501 Spanish Verbs. If you think you can accomplish fluency in Spanish as an adult without mastering conjugating Spanish verbs, you are only fooling yourself. This book is an absolute essential resource for learning how to conjugate Spanish verbs.

If you have any questions about Practice Makes Perfect’s Spanish Conversation, please post your questions below and I will do my best to answer your questions.

0 of 0 people found the following review helpful.
Speak Spanish!
By Eugene R Berman
A nice supplement to The Complete Spanish
Grammar Premium book. I recommend buying!

0 of 0 people found the following review helpful.
Five Stars
By Maria Cohen
Very good book!

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• Original language: French
• Dimensions: 5.71" h x .79" w x 8.46" l,
• Binding: Paperback

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From the Bestselling Author of Salt and The Basque History of the World

Cod, Mark Kurlansky’s third work of nonfiction and winner of the 1999 James Beard Award, is the biography of a single species of fish, but it may as well be a world history with this humble fish as its recurring main character. Cod, it turns out, is the reason Europeans set sail across the Atlantic, and it is the only reason they could. What did the Vikings eat in icy Greenland and on the five expeditions to America recorded in the Icelandic sagas? Cod, frozen and dried in the frosty air, then broken into pieces and eaten like hardtack. What was the staple of the medieval diet? Cod again, sold salted by the Basques, an enigmatic people with a mysterious, unlimited supply of cod. As we make our way through the centuries of cod history, we also find a delicious legacy of recipes, and the tragic story of environmental failure, of depleted fishing stocks where once their numbers were legendary. In this lovely, thoughtful history, Mark Kurlansky ponders the question: Is the fish that changed the world forever changed by the world's folly?

“A charming fish tale and a pretty gift for your favorite seafood cook or fishing monomaniac. But in the last analysis, it’s a bitter ecological fable for our time.” –Los Angeles Times

“Every once in a while a writer of particular skill takes a fresh, seemingly improbable idea and turns out a book of pure delight. Such is the case of Mark Kurlansky and the codfish.” –David McCullough

“One of the 25 Best Books of the Year.” –The New York Public Library

Mark Kurlansky is the author of many books including Salt, The Basque History of the World, 1968, and The Big Oyster. His newest book is Birdseye.

• Sales Rank: #26961 in eBooks
• Published on: 1998-07-01
• Released on: 1998-07-01
• Format: Kindle eBook

Amazon.com Review
You probably enjoy eating codfish, but reading about them? Mark Kurlansky has written a fabulous book--well worth your time--about a fish that probably has mattered more in human history than any other. The cod helped inspire the discovery and exploration of North America. It had a profound impact upon the economic development of New England and eastern Canada from the earliest times. Today, however, overfishing is a constant threat. Kurlansky sprinkles his well-written and occasionally humorous history with interesting asides on the possible origin of the word codpiece and dozens of fish recipes. Sometimes a book on an offbeat or neglected subject really makes the grade. This is one of them.

From Library Journal
In this New York Times best seller, Kurlansky gets us to look at the lowly cod in a whole new light. Search for the lucrative codfish played a key role in the development of the New World. Britain allowed the Colonies to trade with third parties-a milestone on the road to independence-due to a superabundance of cod. We also hear about the evolution of fishing technology that is so successful that cod have come close to extinction and the effect of the 200-mile limit. Moreover, the author relates marvelous Basque, French, British, and New England cod recipes from the last 500 years. Richard Davidson narrates this exceptionally informative and entertaining work.
James L. Dudley, Westhampton, NY
Copyright 2002 Reed Business Information, Inc.

From Booklist
When something is said to have "changed the world," it is either a technological innovation or an article of trade. The North Atlantic cod is the latter, which may come as news nowadays, when it is best known as having virtually vanished from the Grand Banks, ruining the once robust fishing economies of maritime Canada and New England. Kurlansky introduces the delectable white-fleshed fish's long history by taking us out with some Newfoundland fishermen now employed in surveying the remaining cod population. But then he backtracks to tell an epic of transoceanic trade. Cod was for 1,000 years a commodity central to Europe's development and, through Europe, to development in North America, the West Indies, and Africa. Indeed, the Basques of northwestern Iberia and then the Norse discovered America well before Columbus when they probed westward, fishing for cod. Later, the fish became essential to slavery: the best dried cod was exchanged in Europe for goods to be traded for humans in Africa, while lower grades, still highly nutritious, were sold to feed West Indian plantation slaves. That is just some of the grand-scale history Kurlansky relays with maximum readability, plenty of handsome illustrations, and a 40-page appendix of superlatively annotated recipes. Ray Olson

Most helpful customer reviews

77 of 78 people found the following review helpful.
In Cod We Trust!
By Steph
The marvel of Cod: A Biography of the Fish that Changed the World is that anyone could write a book this interesting about a subject so lackluster- a fish so boring that it does not even struggle when it is caught, instead allowing the fisherman to haul it up without a fight. Somehow Mark Kurlansky was able to make the codfish interesting enough that I continually drive my co-workers insane, insisting that they should read this book. Wars have been fought over it, revolutions have been spurred by it, national diets have been founded on it, economies and livelihoods have depended on it. The lowly cod really is the fish that changed the world. This book is a sober reminder of the impact of man on the environment, but it also a enjoyable and readable book filled with curious cod tidbits and a historical cross-section of odd cod recipes. In the same vein as The Perfect Storm or Longitude, this book is more entertaining than either of those maritime titles, although unlikely to be made into a movie starring George Clooney. If seeing the title Cod: A Biography of the Fish that Changed the World made you crack a smile, then you should read this book and tell your friends about it, so that they too can wonder if you're just making it up.

132 of 143 people found the following review helpful.
There's a reason it's widely recommended...
By Keith Smith
If you're one of the many people who's been caught up in the wave of highly focused historical books that have innundated our book stores, then this book is for you. Kurlansky presents the history of one of the most mundane items possible (excepting the humble potato and there's a book on that too) with an engaging and informative style. The book presents as a mix of history, current events, and recipes.
It misfired at times. There is not discussion (or recommendation) regarding management of resources or planning for the future of our fisheries. And some absolute statements (such as the superiour development of Basque cod cuisine) deserve to be challenged. And Kurlansky doesn't consider the fishing history of Native Americans; although, it may be for lack of documentation (I don't know; I'm not a historian; that's why I read these things).
In spite of this, it's an outstanding book. It meets the two key requirements for me in this regard; one, I recommend it to other people who report back on how much they liked it; and two, I'll read it again.
Buy it. Read it. You'll probably enjoy it.

84 of 91 people found the following review helpful.
Fishy Recipe for History and Evolution
By Amazon Customer
There's a cartoon in Matt Groening, the nine types of professors. One is the single-minded type, as in "The country that controls magnesium controls the world!" His main drawback is that he could be right. Cod sort of reminds me of that. You may not have known how important or popular this particular fish was to most of our ancestors in Western civilization, but, according Kurlansky, Cod was practically like bread. It was easy to fish, there was a ton of it, and once Europeans learned the various ways of drying it (with cold and/or salt) all people could think about was trading this staple. Yes, Kurlansky's book is single-minded, and at times you might forget this is a fish tale. When the Vikings found America, what where they looking for? And how did they manage to sustain themselves through the long ocean voyage? The answers are of course, cod. Kurlansky also has a few outlandish things to say about another favorite topic of his, the Basque, who it appears had been regularly fishing for Cod in Newfoundland long before Columbus found America. They were really good at keeping a secret, you see. Fortunately, there's a serious, or, at least more socially acceptable side, to Kurlansky's fish story. The fishing trade really is threatened. You can no longer practically walk on Atlantic cod. Even Icelanders who found their entire economy changing from one of sustenance to a first world service economy, during the two world wars, have a difficult time protecting their dwindling stock. If Aldous Huxley's grandfather, Thomas, asserted in the 19th century that cod would never become extinct, it was only because he could not imagine the rapid technological changes which would turn fishing into harvesting, and the classic practice of drying fish into freezing it, on board the fishing boats themselves. Good bye bacalao, hello fishsticks. It's a sad tale as ways of life dwindle and change, and even the very essentials of human existence that have lasted for thousands of years go unheard of by the post-industrial society. But are we really evolving into something better? Kurlansky peppers his narrative with quotes from notables throughout the ages and interesting, if often archaic, recipes.

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This market-leading text, which reflects recent changes in technology, workplace practices and the global marketplace, progresses from concepts and basic copyediting to comprehensive editing, management and production issues.  The addition of Angela Eaton of Texas Tech University brings a fresh tone to her updates of content and pedagogy while retaining the authoritative voice of Carolyn Rude.  Some of the text's changes include an update ot Chapter 6, "Electronic Editing," and examples about editing Web sites are found throughout the text  to support the increased role of online resources in every aspect of communication.

 

 

 

• Sales Rank: #14111 in Books
• Brand: Rude, Carolyn D./ Eaton, Angela/ Dayton, David (CON)/ Maylath, Bruce (CON)
• Published on: 2010-10-09
• Original language: English
• Number of items: 1
• Dimensions: 9.00" h x 1.10" w x 7.00" l, 1.23 pounds
• Binding: Paperback
• 432 pages

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·        Activities and Case Studies—Document-based Activities and
usability-centered Case Studies will allow you to practice
your knowledge of workplace situations and audiences.

·        Gradebook   Youcan monitor your progress throughautomated grading
of quizzes and assignments.  

 

About the Author

CAROLYN RUDE teaches professional writing and chairs the Department of English at Virginia Tech. Before becoming a professor, she worked as a technical writer and editor. She is past president and fellow of the Association of Teachers of Technical Writing. She is also a fellow of the Society for Technical Communication and winner of its Jay R. Gould Award for excellence in teaching. She believes that understanding editing has enhanced her administrative work, not just because of required writing and document design but also because of the focus of comprehensive editing on readers and purposes, reading styles, and project management.

 

ANGELA EATON (angela.eaton@ttu.edu) is an Associate Professor of Technical Communication and Rhetoric at Texas Tech University. Her research interests include technical editing, grant writing, and technical communication practices and pedagogies. She is the owner of the technical editing and grant writing firm Angela Eaton & Associates, LLC, is a member of the Association of the Teachers of Technical Writing, and is a senior member of the Society for Technical Communication . She was the 2005-2006 winner of the Society for Technical Communication's $10,000 Research Award. Her research has been published in Technical Communication, Business Communication Quarterly, and three edited collections.

 

Most helpful customer reviews

19 of 23 people found the following review helpful.
Excellent for all fields, editors and writers
By A Customer
Dr. Rude did a masterful job of explaining the concepts behind good writing. Reading this book improves your entire writing process by teaching the reader what he should not do when constructing any component within a document, be it a sentence, paragraph, chapter, etc.

It also provides an excellent reference for copy editing symbols, defines the various levels of editing, and defines the roles that writers, editors, and publishers should have.

Overall, Technical Editing has done more to improve my writing than all other writing books combine. It is a must have for your reference library and excellent for classroom instruction

7 of 8 people found the following review helpful.
Somewhat out of touch with the real world
By Ten Thousand Monkeys
A thorough book, but much of the content seems very out of touch with the professional editor's environment and needs. There's a somewhat dated feel to the writing, and when it speaks with about "how things work" in the editing world, it's often wrong. However--parts are useful reference, and a beginner might find several parts useful for some basic understanding of editing. Don't buy this book to learn how to be a technical editor, though.

4 of 4 people found the following review helpful.
Based on 20+ years of experience: Excellent Reference
By Picky Reader
When I "fell into" the technical editing profession more than 20 years ago, there were no or few undergraduate or graduate programs in technical communication. My learning was on the job, and I was very fortunate to work under extremely talented editors who were willing to share everything they knew. I am now a highly respected technical editor for an international corporation. A new colleague, recently graduated with an M.S. in the field, introduced me to this book, which he had used in school. The chapters on copyediting and comprehensive editing in particular are excellent; the process descriptions are right on target. I highly recommend this book for both the theory and practise of technical editing.

See all 31 customer reviews...

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• Sales Rank: #598345 in Books
• Published on: 2016-06-04
• Original language: English
• Dimensions: 9.00" h x .46" w x 6.00" l,
• Binding: Paperback
• 204 pages

About the Author
Hannah Braime is an author and coach from London, England. She is the founder of Becoming Who You Are (www.becomingwhoyouare.net), where she shares practical psychology-based articles, tools and resources on living with greater courage, compassion and authenticity. You can continue your personal growth journey and get access to free workbooks, audios and book summaries by joining the Becoming Who You Are Library here: http://bit.ly/BWYAlibrary Connect with Hannah online: Website: www.becomingwhoyouare.net Facebook: www.facebook.com/becomingwhoyouare Pinterest: www.pinterest.com/hannahbraime

Most helpful customer reviews

4 of 4 people found the following review helpful.
Real, practical advice that will improve your life
By Will Moyer
*Disclosure: I'm a friend of Hannah's and designed the cover of this book. But I wouldn't be writing this review if I didn't think its content was true.*

A lot of books in the self help category are chocked full of mysticism and guru-speak. You know the stuff: "Toltec shaman Daniel Sujarit will teach you how transcendental meditation and Ayurveda yoga positions can free your consciousness from lure of the ever-expanding ego so you can awaken and transform into an enlightened member of the quantum Earth."

Uh... what?

Well this book is the opposite of that. Hannah is a regular person. She's not handing down enlightenment like some new-age guru. She's talking about practical, day-to-day strategies that will help you take better care of yourself, that will help you avoid unsustainable short-term comforts in favor of developing genuine self-care habits.

Hannah, while drawing from her own experiences, suggests steps you can take to identify your coping strategies and replace them with actions that truly satisfy your needs. And she does it without self-righteousness, without sounding like a guru, and without pushing esoteric spiritual gibberish.

Want better relationships? Want to feel happier and more self-confident? Want to stop cycles of procrastination? How about less self-destructive activities? This book will help you do it, step by step, with tons of practical examples and suggestions.

Highly, highly recommended.

2 of 2 people found the following review helpful.
Thank you, thank you, thank you!
By toasterface
This little book has saved me a ton of time and will probably help me add years to my life. It's like she went through the self help section and said, "here, just read this". I went from fairly ignorant of the self-care process to confident in the fundamentals of self care in a matter of hours.

In the past, in regards to self care, I've made comments like, "yeah great, I cant' nap at 10AM, or live off juice, or afford the spa, I work". This book directly addresses this outlook, and others, while providing such clear guidelines that I was able to implement a small but useful change the same day I read it. No chanting in this book? You mean I could just take 5 and acknowledge something I appreciate? Well, I guess I could. Sounds...practical.

As I read the book It seemed like someone put a bunch of useful stuff all in one place. I enjoyed the fact that the author seems like someone anyone would know. That honest person who says, "yeah, I struggled, failed, and here's how I dealt with it". Nothing over the top just real. This book doesn't teach that self care is easy, it reassures that it is possible, for everyone.

Thanks again to the author, although some part of me still wants to indulge a guru. Maybe spend more time with people in robes? Peace.

0 of 0 people found the following review helpful.
Meet your needs as you move from coping to thriving
By Amazon Customer
I thoroughly enjoyed this thoughtful book.

We are conditioned to sacrifice our needs to others but how can we help if we are not taking care of ourselves? We have internalized our parents and much of our behavior results from their voices. Parts of us split off and stay in a childlike state. But we need to make our own reality and meet our own needs and that is where self care comes in. We need to escape our conditioning, feel our emotions and negotiate.

Self care is our choice. It starts with accepting yourself. Focus on the actions and then empathize. "Guilt = I did something bad. Shame = I am bad." And watch the people around you. Are they meeting your needs? Find your True Believers. Those who recognize your potential. Are you meeting your needs? This comes first. HALT are you hungry, angry, lonely or tired? Take care of yourself first. What can you do to relax and have fun? There are many suggestions in the book. I encourage you to read this and incorporate it into your life. There are many resources referenced in the book as well. Meditate, yoga, journal, sleep, and schedule to meet your needs as you move from coping to thriving.

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Implementing Derivatives Models Les Clewlow and Chris Strickland Derivatives markets, particularly the over-the-counter market in complex or exotic options, are continuing to expand rapidly on a global scale, However, the availability of information regarding the theory and applications of the numerical techniques required to succeed in these markets is limited. This lack of information is extremely damaging to all kinds of financial institutions and consequently there is enormous demand for a source of sound numerical methods for pricing and hedging. Implementing Derivatives Models answers this demand, providing comprehensive coverage of practical pricing and hedging techniques for complex options. Highly accessible to practitioners seeking the latest methods and uses of models, including
* The Binomial Method
* Trinomial Trees and Finite Difference Methods
* Monte Carlo Simulation
* Implied Trees and Exotic Options
* Option Pricing, Hedging and Numerical Techniques for Pricing Interest Rate Derivatives
* Term Structure Consistent Short Rate Models
* The Heath, Jarrow and Morton Model
Implementing Derivatives Models is also a potent resource for financial academics who need to implement, compare, and empirically estimate the behaviour of various option pricing models. Finance/Investment

• Sales Rank: #1174322 in Books
• Published on: 1998-06
• Original language: English
• Number of items: 1
• Dimensions: 9.96" h x .98" w x 6.99" l, 1.61 pounds
• Binding: Hardcover
• 330 pages

From the Publisher
As the market for new derivative instruments continues to expand both in volume and complexity, traders and brokers everywhere are clamoring for sound, numerical techniques to model, price and comfortably hedge complex, exotic options. Highly accessible to practitioners seeking the latest uses of Monte Carlo and Binomial methods, this book is also a potent resource for financial academics who need to implement, examine and empirically estimate the behavior of various options pricing models.

From the Inside Flap
As the market for new derivative instruments continues to expand both in volume and complexity, traders and brokers everywhere are clamouring for sound numerical techniques to model, price and comfortably hedge complex, exotic options. Implementing Derivatives Models is the single comprehensive source of this application-oriented guidance. Written in a highly accessible style, it is of great assistance to practitioners and finance academics who need to implement models, examine their behaviour, compare with new models, and perform empirical estimation of the models.

From the Back Cover
Implementing Derivatives Models Les Clewlow and Chris Strickland Derivatives markets, particularly the over-the-counter market in complex or exotic options, are continuing to expand rapidly on a global scale, However, the availability of information regarding the theory and applications of the numerical techniques required to succeed in these markets is limited. This lack of information is extremely damaging to all kinds of financial institutions and consequently there is enormous demand for a source of sound numerical methods for pricing and hedging. Implementing Derivatives Models answers this demand, providing comprehensive coverage of practical pricing and hedging techniques for complex options. Highly accessible to practitioners seeking the latest methods and uses of models, including
* The Binomial Method
* Trinomial Trees and Finite Difference Methods
* Monte Carlo Simulation
* Implied Trees and Exotic Options
* Option Pricing, Hedging and Numerical Techniques for Pricing Interest Rate Derivatives
* Term Structure Consistent Short Rate Models
* The Heath, Jarrow and Morton Model
Implementing Derivatives Models is also a potent resource for financial academics who need to implement, compare, and empirically estimate the behaviour of various option pricing models. Finance/Investment

Most helpful customer reviews

0 of 0 people found the following review helpful.
A great reference and complement to Hull
By Ian K.
Implementing Derivatives Models is a great reference for anyone who need to implement derivative models. The algorithms and the underlying ideas are clearly explained. Each model has a numeric example that you can use to check the results of your model. This really is almost a required reference for anyone building software derivative models (a group that seems to be rather small these days).

I used Implementing Derivative models along with Hull (Options, Futures, and Other Derivatives) for a graduate course I took. Hull writes for MBAs and the models in his book are implemented in Excel, which is, generally, a tool for those who cannot write software. Implementing Derivatives Models is a book for those who are able to implement software in languages like R, Mathlab or C++. Each model in the book includes pseudo-code.

I think that the book doesn't target any language is a feature, but for those looking for C++ algorithms it may be a bug. Unlike books like Numerical Methods in Finance with C++ the books usefulness doesn't depend on which language you are using.

I really can't think of any strong flaws. The book is dense and you have to read it carefully. However, it deals with complex models which require a lot of thought. Perhaps it could have covered issues of numerical convergence a bit more.

0 of 0 people found the following review helpful.
Errata should be more readily available for this book
By MJE
Quite a bit of errors in the book and the errata is difficult to find.

0 of 0 people found the following review helpful.
Great book
By Ken
Learnt a great deal from this book. I bought this because I had to learn some stuff for work, on a project. The book helped me learn the concept easily and understand the content.

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A thorough understanding of cellular and molecular mechanisms involved in the individual expression of toxic effects provides an important tool for assessment of human health risk. New aspects, major advances, and new areas in molecular and cellular biology and toxicology demand updated sources of information to elucidate the functional mechanics of human toxicology.

Mechanistic Toxicology: The Molecular Basis of How Chemicals Disrupt Biological Targets, Second Edition retains the accessible format of the original to present the general principles that link xenobiotic-induced toxicity with the molecular pathways that underlie these toxic effects. Extensively illustrated, this book forms a conceptual bridge between multiple events at the molecular level and the determinants of toxicity at the physiological and cellular level. Specific examples of drugs, environmental pollutants, and other chemicals are carefully chosen to illustrate and highlight the fundamental mechanisms of toxicity at different toxicokinetic and toxicodynamic levels. The book includes references and review articles at the end of each chapter, as well as boxed text for relevant review information on biological, biochemical, molecular, and toxicological background. Linking molecular pathways to more general biomedical contexts, the author ensures that the reader is not lost in the details and instead receives a broad understanding of the processes underlying xenobiotic toxicity.

New in the Second Edition

Updated chapters

Types of toxic responses

Disruption of signal transduction by xenobiotics

Disruption of mitochondrial function

Novel mechanisms derived from systems toxicology

• Sales Rank: #1675403 in Books
• Published on: 2007-03-23
• Released on: 2007-03-23
• Original language: English
• Number of items: 1
• Dimensions: 9.25" h x .94" w x 6.13" l, 1.72 pounds
• Binding: Paperback
• 416 pages

Review
'Students taking formal training in toxicology would definitely benefit from adding this book to their collection, since it covers many recent advances in the field.' - British Toxicology Society Newsletter

'This recently-published volume is a clear state-of-the-art explanation and description of how chemicals disrupt biological targets on a molecular basis. It is a beauty!'. - Toxicology Letters

About the Author
University of Connecticut, Storrs, USA

Most helpful customer reviews

0 of 0 people found the following review helpful.
Mechanistic Toxicology is technical, well-organized, and well-researched synopsis of the fundamentals of Toxicology.
By D. Mullins
A highly technical textbook to the undergraduate student but a toxicological review informed by more relevant examples to the expert, Mechanistic Toxicology is a well-organized and well-researched synopsis of the fundamentals of Toxicology.
Chapters are structured to present the topics first in the "Contents" section, dive deeper into each topic with helpful headings and examples, summarize and simplify what was presented in the "Learning Points" section, and lastly, to suggest further reading. Examples provided in the body of each chapter can get highly technical, though the main points of the chapter are never lost in even the most extended example.
The abundance of examples and in-depth discussions on specific mechanisms makes this book optimal for someone who already has some background in biology and an understanding of toxicological concepts. The reader who hopes to develop a basic understanding of toxicology should look elsewhere, unless that reader is willing to commit substantial amounts of time pulling the basics out of the somewhat technical contents of this book
Finally, the review question and answer section in the back of the book and the index are useful tools that demonstrate the author's ability to make technical concepts more understandable, considering that the reader has some background in related topics. The book is well equipped to explain concepts that may be beyond that reader's understanding.

Chapter-By-Chapter Synopsis:
Below, the title and a summary sentence is given for each chapter.

Ch1 Introduction
An overview of what toxicology investigates and the meaning/importance of both toxicokinetics and toxicodynamics.

Ch. 2. Organ-selective Toxicity
Organ-selective toxicity is based on some of the toxicokinetic and toxicodynamic factors discussed in the previous chapter.

Ch. 3 Cellular Transport and Selective Accumulation of Potentially Toxic Xenobiotics
Structures and the properties resulting from structure of substances, coupled with transport proteins and membrane composition, determine if a xenobiotic can enter a cell and remain there long enough to demonstrate toxic effects.

Ch. 4 Bioactivation of Xenobiotics and Reactive Metabolites
Toxicity is often induced when a substance is metabolized from its original form.

Ch. 5 Xenobiotic-induced Oxidative Stress: Cell Injury, Signaling, and Gene Regulation
Oxidative species are created all the time in equilibrium with antioxidants, but when the equilibrium favors oxidative species (ROS, RNS) cell damage occurs.

Ch. 6 Disruption of Cellular Calcium Homeostasis
Calcium is critical in regulating cell metabolism, activating enzymes and other proteins, and acting as a second messenger, but different xenobiotics can interfere with calcium in all of these processes.

Ch. 7 Mechanisms of Necrotic and Apoptotic Cell Death
Necrosis is relatively random and unorganized cell death, whereas apoptosis is organized cell death that involves signals received by death receptors, action by caspases and checkpoints along the way.

Ch. 8 Impairment of Cell proliferation and Tissue Repair
Xenobiotics and induce or impair cell proliferation.

Ch. 9 Covalent Binding of Reactive Metabolites to Cellular Macromolecules
Some Xenobiotics can be activated into an electrophile that reacts with protein or DNA nucleophiles, forming covalent bonds.

Ch. 10 Immune Mechanisms
Xenobiotics can inhibit immune response, increasing chances of infection, or increase immune response, causing damage through autoimmune action.

Ch. 11 Cytokine-mediated Toxicity
Proinflammatory cytokines and chemokines can enhance or mediate toxicity.

Ch. 12 Specific Inactivation of Enzymes and Other Proteins
Some xenobiotics target very specific proteins, organophosphates being a good example of this in their tendency to target acetylcholine esterase.

Ch. 13 Nuclear Receptor-Mediated Toxicity
Some xenobiotics can bind to nuclear receptors and disrupt normal processes.

Ch. 14 Interactions of Xenobiotics With Ion Transporters
Some xenobiotics can bind to ion channels and ion pumps, disrupting critical functions, like the action of sodium-potassium pumps.

Ch. 15 Disruption of Cellular Energy Production by Xenobiotics
Xenobiotics interference of mitochondrial activity results in a cellular energy crisis and can add to the production of ROS (addressed in Ch. 5).

Ch. 16 Outlook: From Mechanisms to Individual Expression of Genes
Major advances including DNA sequencing and advances in molecular technology is helping provide massive quantities of data still requiring interpretation.

The author, Urs A. Boelsterli, currently serves at the Chair in Mechanistic Toxicology in the Department of Pharmaceutical Sciences at the University of Conneticut. He earned a M. Sc. And Ph. D. from the University of Zurich and did his postdoctoral work at the University of Toxicology in Zurich, Switzerland. His most recent publication, Pharmacologic targeting of bacterial β-glucuronidase alleviates nonsteroidal anti-inflammatory drug-induced enteropathy in mice, was published in 2012. He is also on the editorial board of Toxicology Mechanisms and Methods.

0 of 0 people found the following review helpful.
Must have for any tox student
By RiisRiss
My only complaint for this book is the lack of chemical equations but beyond that this book is absolutely wonderful. I discovered it accidentally while doing an assignment from the Google preview and knew I should have it to prepare for my qualifying exams. It has all the classic toxic agents, gives history of them, and the explanations for the mechanisms are simple, easy to understand and quite detailed. And when a toxicant has multi-system effects he references them for you, so it's easy to keep track. He also provides his sources for further reading at the end of the chapter. I love this book!

0 of 3 people found the following review helpful.
Excellent Toxicology Book
By Calivarathan Latchoumycandane
It is one of the best toxicology books with mechanistic approach, simple to understand, lots of information.

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[Q905.Ebook] Ebook Analysis, Synthesis, and Perception of Musical Sounds: The Sound of Music (Modern Acoustics and Signal Processing)From Springer

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This book contains a complete and accurate mathematical treatment of the sounds of music with an emphasis on musical timbre. The book spans the range from tutorial introduction to advanced research and application to speculative assessment of its various techniques. All the contributors use a generalized additive sine wave model for describing musical timbre which gives a conceptual unity, but is of sufficient utility to be adapted to many different tasks.

• Sales Rank: #2526160 in Books
• Published on: 2006-12-19
• Original language: English
• Number of items: 1
• Dimensions: 9.21" h x .81" w x 6.14" l, 1.32 pounds
• Binding: Hardcover
• 328 pages

From the Back Cover

Analysis, Synthesis, and Perception of Musical Sounds contains a detailed treatment of basic methods for analysis and synthesis of musical sounds, including the phase vocoder method, the McAulay-Quatieri frequency-tracking method, the constant-Q transform, and methods for pitch tracking with several examples shown. Various aspects of musical sound spectra such as spectral envelope, spectral centroid, spectral flux, and spectral irregularity are defined and discussed. One chapter is devoted to the control and synthesis of spectral envelopes. Two advanced methods of analysis/synthesis are given: "Sines Plus Transients Plus Noise" and "Spectrotemporal Reassignment" are covered. Methods for timbre morphing are given. The last two chapters discuss the perception of musical sounds based on discrimination and multidimensional scaling timbre models.

About the Author

James W. Beauchamp has been working in the area of analysis, synthesis, and perception of musical sounds for over 40 years. He is editor and co-author of Music by Computers (Wiley, 1969), a fellow of the Audio Engineering Society and of the Acoustical Society of America, former president and board member of the International Computer Music Association, and has published numerous papers in the Journal of the Audio Engineering Society, the Journal of the Acoustical Society of America, the Computer Music Journal, Proceedings of the International Computer Music Conference, Proceedings of the International Conference on Music Perception and Cognition, Proceedings of the International Society of Musical Acoustics, and Proceedings of the IEEE Workshop on Applicatiions of Signal Processing to Audio and Acoustics. For over thirty years at the University of Illinois at Urbana-Champaign he taught courses on musical acoustics, electronic music, and computer music (in the School of Music) and audio engineering, electronic music synthesis, and acoustics (in the Department of Electrical and Computer Engineering). During spring, 1988 he was a visiting scholar at the Center for Research in Music and Acoustics at Stanford University, and during 1994-95 he was a visiting researcher at the Institute for Research and Coordination in Acoustics and Music in Paris. His research interests have been in electronic and computer music synthesis systems, analysis, synthesis, and perception of musical instrument sounds, automatic pitch detection, and instrument separation.

Most helpful customer reviews

6 of 6 people found the following review helpful.
Excellent book on audio signal processing & musical timbre
By Charles Cooper
Covers both the "classic" techniques and some very recent advances in the analysis, modification and synthesis of musical sounds. The chapters on the psychoacoustics of musical timbre are excellent. I've got virtually every available book in the general area of audio signal processing and musical psychoacoustics, and this one is clearly the best so far. Chapters are contributed by several different authors. They provide both a clear review or summary of each topic and some cutting-edge "goodies" describing recent research and techniques in areas such re-synthesis of transients and noise, frequency tracking, and sound morphing.

2 of 2 people found the following review helpful.
Discovering the Beauty of Musical Sound: A Must-Have for Music Signal Processing Novice and Expert
By Michael (Gang) Ren
This book covers a major area of music signal processing, namely analysis, synthesis and perception (AS&P) of musical sound. The book is nicely written by leading experts in this field and coherently organized. In the analysis part, the authors provide important tools for investigating the internal structure of musical sound. These tools also serve as important feature extractors for content-based music information retrieval (such as multimedia search). The synthesis part is a nice extension for analysis. First, because analysis and synthesis are essentially always connected in concept and practice of Music DSP (such as "analysis by synthesis"), the synthesis part in this book is naturally part of the core arsenal of sound analysis. Second, musical sound synthesis has its own applications, the same as speech synthesis. The perception part is also nicely written and provides complete examples of cognition experiments with a summary of experimental results.

This book is important for graduate students, academic researchers, and industry developers working in the field of music signal processing. Besides covering the fundamentals of music SP, this book clearly outlines current research frontiers (and open problems). The algorithms are clearly illustrated and many have readily available implementations. I feel the majority of the available books on music SP are too close to speech SP (or they treat music SP as a "recent" extension from speech SP). This book is unique because it is specifically targeted to music (as the editor points out in the preface, music SP also has a very long research tradition). Another reason that I find this book appealing is that the most essential tools can be learned and implemented quickly. The book is edited in a consistent narrative style so it is easy to navigate. The depth in most chapters is masterfully arranged so the basics are covered first and then the advanced materials are included. I think this "structure" feature is important because it relieves the readers from having to perform extensive literature search themselves while maintaining easy readability.

2 of 3 people found the following review helpful.
Concise, Accurate, Comprehensive, Logical, Practical.
By Michael Tsiappoutas
I have been using this book on and off for the last 3 years, and intensely for the last year and a half, as part of my Ph.D. dissertation in Engineering and Applied Science---Physics. I have used directly only the first chapter, the only one written by the Editor, James W. Beauchamp. I've glanced through the rest of it, but my review is largely based on this first chapter.

Professor Beauchamp's organization and presentation of the material is amazingly clear and logical. This becomes more apparent when one considers (recent) literature on this very specialized field, acoustical digital signal processing (DSP). That been said, the material is not easy to grasp for the reader not familiar with DSP and acoustics fundamentals. The mathematical theory has a natural hierarchical structure and every single equation in the first chapter is justified. I could be hard-pressed to single out one equation or concept that does not add considerable value to this product.

I particularly enjoyed the deliberate emphasis on the interdisciplinarity of the subject. DSP, acoustics theory (both from a physics and an engineering perspective), and psychoacoustics all blend well, their parts carefully weighted to give the reader a working knowledge of each part's contribution. Intuitive as this may sound, it is not common practice in the general acoustics DSP literature. It takes a person with immense practical experience and theoretical background to achieve that. Professor Beauchamp's central role in this space is grounded on years of relevant teaching at the Univ. of Illinois (Urbana-Champaign) as well as his expertise on practical applications of this material.

Everything presented in the first chapter can be readily applied using Dr. Beauchamp's free software, SNDAN, on both Windows/DOS and Unix platforms, and can be found here . Once downloaded, the user can push his acoustic signals (saved as .wav files) by calling one of two functions, the Phase Vocoder analysis, or the McAuley-Quatieri analysis. Even though this is not a GUI application, the commands are sequential in the sense that once you upload the .wav file and chose which method you want to run, the DOS prompt asks you what you want to do next, like, for example, plot certain harmonics (only fundamental, or a weighted average of the first harmonics based on psychoacoustical experiments), spectral irregularity (corresponding to a feeling of "jaggedness"), normalized spectral centroid (corresponding to the percieved quality of sound brightness), amplitude or frequency over time, amplitude vs. frequency, amplitude vs. frequency over time (3-D plots), musical pitch vs. time (actual musical tones), and more. Another capability is raw calculation of fomulas presented in the first chapter of the book, like for example spectral centroid averages (so you can compare your signal to the perceived brightness of certain instruments), or the linear regression equation of a suggested analysis frequency for the Phase Vocoder method. Another notable feature is its ability to manipulate the signal by substituting certain spectral regions with root mean squares or weighted or straight averages of the same spectrum, apply filetring, smoothing, and being able to export the data as a raw ASCII file for further manipulation in other software like MATLAB, SAS, or R. Yet another cabability is its smart re-synthesizing of manipulated signals, something i have not had the chance to explore yet. As a matter of fact, SNDAN is so flexible, that it can be of as much use to the practicing sound engineer as it can be to the researching/teaching professor or graduate student. An ideal tool for sound lab demos and practice. If you download SNDAN and run your data through it, you will see so many interesting pictures of your signal, you will be tempted to buy the book so you can understand their meaning. And the first chapter of the book does justice to the peice of software. By the way, the rest of the chapters are not implementable in SNDAN.

The rest of the chapters feature well-established names, like Dr. Judith C. Brown (inventor of the Q-transform). I have not worked with timbre, but from what little i know, it seems like the treatment is as comprehensive as it is cutting-edge [three (3) out of a total of eight (8) chapters dedicated to it]. Fundamental frequency estimation, sound synthesis, spectral envelopes as additive models, and data reduction is some other topics covered.

The book is concise and can be read as a stand-alone source, the information is accurate and up-to-date, economical yet comprehensive, the material throughout is presented logically, and the theory is readily applied using the author's software, SNDAN. A wonderful and needed publication in the field of acoustical DSP, indeed.

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